Clinical Manifestations and Pathophysiology of Sarcopenia


Mitsutaka Yakabe, Sumito Ogawa*, Masahiro Akishita

Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Abstract: Sarcopenia is an age-related condition characterized by low muscle mass and low physical performance. Several groups have established diagnostic criteria for sarcopenia, which include usual gait speed, skeletal muscle mass and grip strength. In this article, we summarize these criteria, pathogenesis, epidemiology, related conditions and possible interventions for sarcopenia.

Keywords: Sarcopenia, Frailty, Vitamin D, Testosterone, Nutrition, Inflammation


Sarcopenia is characterized by loss of muscle mass, strength and function. This debilitating condition is common in the elderly and results in frailty, disability 1, and high mortality 2. The number of elderly population with sarcopenia is increasing all over the world, and it is becoming an important public concern 3.

The word “sarcopenia” is derived from Greek sarx(flesh) and penia’ (loss). This term was first proposed by Rosenberg in 1988, originally indicating muscle mass loss caused by aging 4. The range of muscle decrease included in sarcopenia was controversial, and there was no conclusive definition of sarcopenia. In 2010, European Working Group on Sarcopenia in Older People (EWGSOP) defined sarcopenia as “a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life and death” 5. Then sarcopenia have gradually come to be known to clinicians and researchers.

This scientific paper published in journal RNA and Transcription, if you like, you can read full scientific paper in SciencePG for free.

Click here to read the full scientific article:

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s